HBV Capsid inhibitor 3711 ( Compound 3711 )

Catalog No. M13173 CAS No. 2041072-40-4

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Product Name

HBV Capsid inhibitor 3711
Note

Research use only, not for human use.
Brief Description

HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor.
Description

HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain.
Synonyms

Compound 3711
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

——
Indication

——

CAS Number

2041072-40-4
Formula Weight

367.83
Molecular Formula

C20H18ClN3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

N-(4-(1-(4-chlorobenzyl)-5-methyl-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)acetamide

1. Feng S, et al. ACS Infect Dis. 2018 Mar 9;4(3):257-277.
2. Wang YJ, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):7061-72.

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